Genetics

Researchers from Lund University in Sweden have discovered that out of all cruciate ligament injuries, 69% can be explained by genetics.

This discovery may have important implications when predicting those individuals who are at higher risk of developing this type of knee injury. It will also enable more individualised injury prevention plans.

Anterior Cruciate Ligament (ACL)

The anterior cruciate ligament (ACL) injury is one of the most commonly occurring knee injuries and is especially common among those who undertake sports on both amateur and professional levels.

The anterior cruciate ligament is a ligament in the knee which joins the femur (upper leg bone) with the tibia (lower leg bone) and its primary purpose is to keep the knee stable. It is commonly injured through motions such as sudden stops, changes in direction, and after jumping and landing with impact.

Genetic Origin

The more obvious risk factors, particularly for those in sports, that result in an anterior cruciate ligament rupture include playing on surfaces with high friction, and making sudden stops or pivoting. However new research is suggesting that it is also associated with risk factors that have a genetic origin. This includes bone geometry of the knee, malalignment and generalised joint laxity. This type of injury has also been linked to hypermobility.

An anterior cruciate ligament rupture can lead to reduced quality of life and is associated with up to 10 fold increased risk for developing osteoarthritis of the knee.

Osteoarthritis Genes Discovered

Almost 9 million people in the UK suffer from osteoarthritis, a degenerative joint disease where joints become damaged, painful and often very restricted. There is no current treatment for osteoarthritis and it is often managed through pain relief and often eventual surgery.

New research investigating the genetics behind osteoarthritis has revealed nine novel genes for osteoarthritis which will help to identify genetic risk factors for the disease. This might be a stepping stone into the understanding of osteoarthritis and the development of treatments.

By revealing how these genes contribute to osteoarthritis, this research could open the door for new treatments to help millions of people.

Get In Touch

If you have concerns about your knees and have a family history of knee joint problems, Mr Punwar can carry out a thorough examination, as well as MRI scans if necessary.

Mr Shah Punwar is highly experienced in treating ACL tears, as well as treating those with osteoarthritis. He can help advise on how to manage your condition and give you a personalised treatment plan. Get in touch and book a consultation today.

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